Mindstate Design Labs is building the closed-loop science and engineering stack for rational psychoactive effect design. The company’s molecular-experience interface links molecular biology to the human psychopharmacodynamic profile to convert informal constructs like clarity, presence, or motivation into high-dimensional design targets. Its clinical program is a sequence of human demonstrations that psychoactive effects can be decomposed, recombined, and synthesized. The first controlled study decomposed hallucinations from the broader hallucinogen profile; the next is designed to selectively upregulate aesthetic salience to treat anhedonia in major depressive disorder. Founded by Dr. Tom Ray, creator of programmable evolution, and Dillan DiNardo, a biotech investor and serial operator who previously founded platforms in programmable genes, proteins, and cells. Backed by the founders, CEOs, and founding investors of the companies that built frontier AI and biology (OpenAI, Anthropic, DeepMind, Neuralink, Valo, Y Combinator) and new category infrastructure (Coinbase, Instacart, AngelList, Twitch).